SPP1 and central nervous system cancer: In line, Sankowski et al., identified two human glioma-associated microglia (GAMs) clusters with low expression of the microglia core genes, including CX3CR1 and SELPLG, and high expression of metabolic, inflammatory, and interferon-associated genes such as CD163, SPP1, APOE, LPL, and IF127. In addition, these clusters presented a MHC II gene signature similar to glioma-associated microglia cells in mice.