KDM8 and familial dilated cardiomyopathy: Kdm8 deletion in a broader population of cardiac progenitors using Nkx2-5-Cre48 (Extended Data Fig. 3a) caused DCM that progressed beyond 20 months of age (Extended Data Fig. 3b–d), perhaps because of less efficient recombination in cardiomyocytes (Extended Data Fig. 3a)48, or non-cardiomyocyte-mediated compensatory effects.