In rat BMSCs isolated from osteoporosis models, overexpressing METTL3 restored the osteogenic ability by activating the Wnt/β-catenin signaling pathway and subsequently increased the expression of β-catenin, RUNX2, OPN, P-Gsk-3β, and Lef1 [31]. The gene discussed is METTL3; the disease is osteoporosis.