ZFHX3 and colonic neoplasm: SYNE1 is involved in cell cycle progression and is implicated in numerous malignancies including lung, ovarian, and colon cancers.13 One analysis of The Cancer Genome Atlas glioblastoma samples reported that SYNE1 mutation was associated with higher expression of the oncogene RAF1 and decreased expression of tumor suppressors MTUS1, ZFHX3, and SPINT2.