EGFR mutations, amplifications, and expression of the EGFRvIII variant occur frequently in glioblastoma; previous studies have reported varying results regarding the prognostic value of EGFR alterations.24 Although EGFR has received much attention as a potential therapeutic target, little success has been achieved via targeting EGFR signaling in glioblastoma. This evidence concerns the gene EGFR and glioblastoma.