CD68 and glioma: CD68 is a marker used to identify TAMs in cancer tissue samples, and the presence of CD68-positive cells is correlated with an immunosuppressive tumor microenvironment and worse prognosis.19 CIBERSORT analysis revealed no significant differences in percentages of TAMs in male versus female tumors, suggesting that differences in CD68 expression may reflect glioma rather than immune cell CD68 expression.