STAT3 and central nervous system cancer: Another study investigated the role of glioma-associated macrophages in promoting the invasive phenotype of glioblastoma and found that monocytic cells releasing IL-6 induced ODZ1 expression and contributed to invasiveness via a Stat3-mediated mechanism; Blockade of this signaling pathway decreased ODZ1 expression and glioblastoma invasiveness.18 These findings suggest that further investigation of TENM1 signaling would be valuable to determine the prognostic implications of alterations in this gene in glioblastoma.