Transcriptomic analysis revealed 14 transcripts (DNAJB5, PHTF2, TIPRL, CDC23, PGRMC2, CDKN2A, EXOSC9, MIS18BP1, RFC4, CNOT6, IQGAP2, AP3M1, ZNF521, and EPC1) expressed at a significantly higher level in the LTS cohort, and two transcripts (TMBIM1 and CLSTN1) expressed significantly more frequently in STS patients (q ≤ 0.05). The gene discussed is CLSTN1; the disease is telomere syndrome.