The activation of HER2 receptors can be induced by hetero- or homodimerization with HER2 (Hsu and Hung, 2016) or other members of the ERbB/HER family, such as HER3 or EGFR, in both normal and tumor cells (Altiok et al., 1995, Gandullo Sánchez et al.,2022). This evidence concerns the gene ERBB3 and neoplasm.