Mutations affecting the innate immune system (e.g., NOD1, NOD2, TLR2, CD14, DEFB1) and adaptive immunity (e.g., IL-4, IL-4RA, IL-13, TSLP, IL-31, CCR5) have been linked to AD, highlighting the role of genetic and environmental factors in its development [12]. This evidence concerns the gene IL4 and Alzheimer disease.