If the hs-cTnI levels do not trend down beyond 48 h, this may suggest that hs-cTnI level may not be due to myocardial injury from the surgical intervention alone, although we did not observe in our cohort any significant coronary artery disease that could explain hs-cTnI rise, and the association could be explained by clinical worsening, oxygen supply-demand mismatch or decreased hs-cTnI clearance. Here, TNNI3 is linked to coronary artery disorder.