There were no coronary plaque ruptures documented, no significant CAD before surgery, no need for revascularization during hospital admission and no correlation with left ventricular ejection fraction, suggesting that hs-cTnI rise is explained by factors related to the surgical intervention and the postoperative course, especially since the LTx operation necessitates cutting and sewing the atrial myocardium, and the rise in hs-cTnI does not reflect coronary artery disease. Here, TNNI3 is linked to coronary artery disorder.