The factors secreted by stromal cells or cancer cells that can promote EMT include TGF-β (Potts and Runyan, 1989; Miettinen et al., 1994), HGF (Liu et al., 2017), FGF (Vallés et al., 1990), EGF (Sheng et al., 2020), Wnt (Kim et al., 2002) and Notch (Timmerman et al., 2004). This evidence concerns the gene TGFB1 and cancer.