The IGF-1/IGF-1R signaling can activate the PI3K/AKT/mTOR pathway signaling pathway (Abdel-Wahab et al., 2018), which is closely related to AKT1 and PIK3CD and plays a critical role in glioma progression, promoting cancer cell proliferation and inducing drug resistance. The gene discussed is IGF1R; the disease is glioma.