The IGF-1/IGF-1R signaling can activate the PI3K/AKT/mTOR pathway signaling pathway (Abdel-Wahab et al., 2018), which is closely related to AKT1 and PIK3CD and plays a critical role in glioma progression, promoting cancer cell proliferation and inducing drug resistance. The gene discussed is AKT1; the disease is central nervous system cancer.