Research by Fanok et al. using this model revealed that dysregulated cytokine signaling, particularly aberrations in the IL-2 receptor signaling pathway and the JAK-STAT signaling pathway, as well as imbalances in microenvironmental factors, like the skin microbiome, may promote the onset and progression of CTCL (Fanok et al., 2018). The gene discussed is SOAT1; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.