Hnrnpk flox CD4CreERT2 mouse model can be utilized to examine the impact of HNRNPK gene haplodeficiency or its complete absence in CD4+ T cells, aiming to elucidate its role in CTCL pathogenesis (Bastidas Torres et al., 2018; Park et al., 2021). The gene discussed is HNRNPK; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.