In addition to its role in modulating cellular and viral protein synthesis, the IFN response also regulates the host response to viral infection by stimulating the upregulation of major histocompatibility complex class I and II antigens (28, 29), promoting programmed cell death (30–32), regulating cellular differentiation (33), suppressing angiogenesis (34), and activating other immune cells (35, 36). This evidence concerns the gene IFNA1 and viral infectious disease.