Sodium valproate, a low affinity pan HDACi, can induce the expression of NKG2D ligands MICA, ULBP2, and ULBP3 in tumor cells, including primary patient acute myeloid leukemia (AML) cells, resulting in enhanced CD107a degranulation of NK cells. The gene discussed is KLRK1; the disease is acute myeloid leukemia.