EZH2-mediated DNA methylation associated with DNMT1 and H3K27me3 may inhibit the expression of the type 1 T helper cell (TH1) chemokines CXCL9 and CXCL10, as well as the subsequent transport of effector T cells to the tumor microenvironment [64]. This evidence concerns the gene CXCL9 and neoplasm.