However, further studies using the NASH mouse model induced by a diet deficient in methionine and choline (MCD) showed that ASO-mediated DGAT2 silencing aggravated hepatic inflammation and fibrosis via elevated FFA-associated oxidative stress,310 indicating critical roles of non-TG lipid products initiating hepatotoxicity in NASH progression. The gene discussed is DGAT2; the disease is metabolic dysfunction-associated steatohepatitis.