PLOD1 and angiosarcoma: • Multiplicity of drug targets precludes confident prediction of tumor outcome in rats• Extrapolation of findings from class not warranted based on differences in pharmacology• Potential impact of hormonal changes detected in the rats (LH/FSH) were not sufficiently addressed• In the 26-week rat study, increases in hemorrhagic cystic degeneration in the lymph nodes which might be related to hemangiosarcomas in female rats