CRP and Alzheimer disease: Stimulation of the vagus nerve reduced systemic inflammation, circulating CRP, and symptoms in a series of Crohn’s patients [22], while electroacupuncture-mediated activation of the vagal-adrenal axis in a murine model of transgenic Alzheimer's disease significantly reduced neuroinflammation via NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) and IL-1β perturbation, concomitantly protecting against cognitive decline [23].