Differences in nighttime sleep architecture have been reported between NT1, NT2 and IH; most notably, orexin deficiency in NT1 may lead to changes in the evolution of sleep architecture and continuity throughout the night that could separate patients with NT1 from individuals with intact orexin systems, for example, patients with NT2 or IH (Barateau et al., 2020). Here, HCRT is linked to hyperinsulinemic hypoglycemia, familial, 4.