It is worth noting that we have identified hub genes associated with lipid metabolism (INHBE, PCK1, APOA4, APOA1) and apoptosis (KIT, NTRK2) together with PPAR and MAPK signaling pathway, especially PCK1, which may be the pathogenesis and potential therapeutic targets of FLHS. The gene discussed is APOA1; the disease is Floating-Harbor syndrome.