APOA4 and Disorder of lipid metabolism: In this model, the HFD may trigger histone modification of H3K27ac, leading to dysregulation of candidate genes associated with lipid metabolism (PCK1, APOA4, APOA1) and apoptosis (KIT, NTRK2) together with PPAR and MAPK signaling pathways, which results in lipid metabolic disorders and dysregulation of apoptosis inducing the formation of FLHS.