CDH2 and glioblastoma: Fibrinogen is cleaved by thrombin, resulting in the formationof fibrin which is a cross-linked type of hydrogel.19,128 Therefore, fibrinogen and thrombin were used altogether in the studiesthat created 3D bioprinted GBM and NB models.6,23,26,129 For instance,a bioink including fibrinogen, genipin, and alginate was cross-linkedwith a blend containing thrombin, chitosan, and calcium chloride.26 Then, N-cadherin antagonist was added onto extrusion-based3D bioprinted GBM models encapsulating U87 GBM cells and astrocytes,leading to considerable cell death relative to controls.