It exhibits a wide range of biological activities in tumor therapy,[8] immune inflammation,[9] neurodegenerative diseases,[10] and metabolic disorders.[11] Although some studies have revealed molecular targets and signaling pathways of celastrol, such as the PI3K/AKT pathway,[12] NF‐κB pathway,[13] STAT3,[14] HSP90,[15] and proteasome,[16] among others,[17] its exact mechanism of action remains incompletely understood. This evidence concerns the gene NFKB1 and neoplasm.