When we quantified the co-occurrence of TDP-43 nuclear depletion and SUN1 disruption in MAP2-positive cortical neurons, we found that almost the totality of the ALS neurons with mislocalized TDP-43 also presented with SUN1 perinuclear disruption (Supplementary Fig. 13), supporting a strong correlation between the two events. Here, MAP2 is linked to amyotrophic lateral sclerosis.