GNAS and amyotrophic lateral sclerosis: We found a significant higher percentage of MNs presenting a weaker or undetectable nuclear localization (i.e. “disrupted” staining) of both SUN and NESP proteins in MNs of sALS and C9-ALS compared with healthy controls, while no significant difference was noted between sALS and C9-ALS (Fig. 4g-h, Supplementary Fig. 6g-h).