EZH2 and neoplasm: To validate the significance of EZH2-dependent integrin α11 in breast cancer progression, that is, whether integrin α11 over EZH2 is the right target to inhibit the growth and metastasis of drug-resistant breast cancers, two different xenograft tumor models were established, one in chick chorioallantoic membrane (CAM) and another in BALB/c nude mice.