CTSG and proximal spinal muscular atrophy: Based on our multi-omic evidence (Figs. 1 and 2) showing overexpression of these NF-kB orthologs in our SMA models, we first ingressed heterozygous mutations for dl and Rel into the background of Cg-Gal4/SmnJF-RNAi flies to reduce dosage of these genes and then scored the resultant progeny for melanotic masses.