Recent studies have shown that intervention with Yupingfengsan exhibited therapeutic effects on LPS-induced ALI mice by inhibiting the activation of NLRP3 inflammasome and the MAPK signaling pathway [253], which highlights the potential of drugs targeting MAPK in ARDS treatment, underscoring the significance of these signaling pathways in the pathogenesis of ALI/ARDS. The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.