Interestingly, when comparing resilient to AD donors, gene sets involved in processes related to mitochondrial functioning were more highly expressed in the resilient group (driven by, amongst others, MT-CO1, MT-CO3, MT-CYB) (Fig. 3E), of which MT-CO3 was also a DEG in the resilient compared to the AD group. Here, MT-CO1 is linked to Alzheimer disease.