Given the overexpression of HSP90 in malignancies such as breast cancer and its documented role in facilitating the inclusion of molecules like IL-1β and RAB22A-NEOF1 into vesicles [39, 40], it is plausible that LAP-TGF-β1 might be incorporated into exosomes through an interaction with HSP90A. This evidence concerns the gene TGFB1 and breast carcinoma.