TFEB and obesity due to melanocortin 4 receptor deficiency: TFEB is one of the MiTF/TFE family members of the leucine zip (bHLH-LZ) class of transcription factors, which have been found to potentially play an important role in a variety of diseases such as lysosomal storage disorders, neurodegenerative diseases, hepatic metabolic disorders, obesity, and others [9, 10, 32].