A previous proteomic study has revealed the presence of high levels of TIMP-1 and TIMP-2 in CM-hUCESC [59], and in the present study we have evidenced that these factor secreted by hUCESC contribute to the regulation of tumor aggressiveness through the inhibition of tumor cell invasion, as well as being implicated in other non-tumor processes induced by CM-hUCESC [24]. The gene discussed is TIMP2; the disease is neoplasm.