Complete CM-hUCESC significantly decreased migration of cancer cell line as compared with control (p < 0.0001, adjusted p value = 0.0007) and with CM-hUCESC lacking TIMP-1 and − 2 (IP TIMP-1/2) (p = 0.004, adjusted p value = 0.008) (Fig. 2D). This evidence concerns the gene TIMP1 and cancer.