GH1 and Cognitive impairment: Manifestations related to resistance to other protein hormones, which act by binding to Gsα‐protein coupled receptors, such as TSH, gonadotropins (FSH/LH) and to lesser extent growth hormone (GH), are also reported in patients with PHP, in association with the phenotypic picture of Albright hereditary osteodystrophy (AHO) characterized by short stature, round facies, subcutaneous ossifications, and brachydactyly and varying degrees of cognitive impairment; obesity is present in some subtypes [2–4].