GPX4 and liver cancer: These findings indicatied that after CK action on liver cancer cells, gathered intracellular Fe2+ and triggered the accumulation of lipid peroxide through fenton reaction, and the systemic xc-’s function was affected, the activity of SLC7A11 was inhibited, thus inhibiting GSH synthesis, resulting in reduced GPX4 activity and increased MDA production, which leaded to cells ferroptosis.