GPX4 and neoplasm: For example, Dihydroartemisinin caused ferroptosis in tumor cells by disrupting the intracellular redox balance [9], Baicalin induced ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis [10], Piperlongumine rapidly induced the death of human pancreatic cancer cells mainly through the induction of ferroptosis [11].