NFKB1 and acute myeloid leukemia: Additionally, Shahmoradgoli et al. propose that CHMP5 may be an oncogenic gene in acute myeloid leukemia due to the anti-apoptotic feature of CHMP5 by inhibiting apoptosis-associated genes and different signaling pathways, including NF-κB (Shahmoradgoli et al. 2011).