RASA1 gene is described as associated with vascular malformation syndromes such as Klippel-Trenaunay-Weber syndrome, Sturgeon-Weber syndrome, vein of Galen aneurysmal malformation, etc. RASA1 is a cytoplasm protein transported to the cell membrane upon increased intracellular Ca2 + concentrations. This evidence concerns the gene RASA1 and angioosteohypertrophic syndrome.