Tumor-type stratification of NEDD4Le13 in TCGA data showed the PSI of NEDD4L to be significantly lower in TNBC tumors compared to normal breast tissue (p = 2.5 × 10−6), luminal tumors (p < 2.22 × 10−16), normal-like tumors (p = 7.9 × 10−7), and HER2+ breast tumors (p = 4.9 × 10−14), indicating that the skipping isoform is more dominant in TNBC tumors (Fig. 4E). Here, ERBB2 is linked to breast neoplasm.