Concerning the AD-related genes, the analysis yielded three genes: APH1B gene common to AD ∩ LC ∩ mOFC ∩ insula ∩ amygdala; GRN gene common to AD ∩ LC ∩ insula; EPDR1 gene common to AD ∩ LC ∩ amygdala (Fig. 4d). Here, GRN is linked to Alzheimer disease.