Subsequently, the 5th edition of the WHO classification of hematological neoplasms (WHO-HAEM5) has adopted this separator for translocations which involve conventional genes and IG and TR loci in hematological neoplasms, also italicizing these genes and IG and TR loci (e.g IGH::MYC and IGH::CCND1) [25]. Here, MYC is linked to hematopoietic and lymphoid system neoplasm.