Using TCGA dataset, 11 genes (UBE2C, PTTG1, TOP2A, SPP1, FCN3, SLC22A1, ADH4, CYP2C8, SLC10A1, F9, and FBP1) were significantly identified to associate with OS, PFS, DSS and DFS in HCC patients. This evidence concerns the gene TOP2A and hepatocellular carcinoma.