TOP2A and hepatocellular carcinoma: Interestingly, among 11 prognosis-related genes, PTTG1 (0.28%), TOP2A (1.12%), FCN3 (0.28%), ADH4 (0.84%), CYP2C8 (1.4%), and SLC10A1 (0.84%) exhibited mutations, such as nonsense mutation, missense mutation, frame shift insertion, and frame shift deletion in HCC patients (Fig. 2B,D).