Using TCGA dataset, 11 genes (UBE2C, PTTG1, TOP2A, SPP1, FCN3, SLC22A1, ADH4, CYP2C8, SLC10A1, F9, and FBP1) were significantly identified to associate with OS, PFS, DSS and DFS in HCC patients. The gene discussed is PTTG1; the disease is hepatocellular carcinoma.