Whereas, to be tumor suppressors, ficolin 3 (FCN3), cytochrome P450 family 2 subfamily C member 8 (CYP2C8), and fructose-1,6-biphosphatase (FBP1) have been reported to be downregulated in HCC and inhibited the progression of HCC. This evidence concerns the gene FCN3 and hepatocellular carcinoma.