Based on these findings, Lip-1 not only suppressed lipid metabolism-related proteins, ACSL4 and LPCAT3, but also restored the levels of GPX4 and xCT, reduced inflammation factors IL-6 and TNF-α, and alleviated ERS-related proteins, contributing to the mitigation of ferroptosis-induced pancreatitis, prominently in HTGP. This evidence concerns the gene ACSL4 and pancreatitis.