Interestingly, in patients with hypercholesterolemia, a HND improves blood lipid profile and insulin sensitivity while also lowering blood pressure to clinically meaningful levels36 In the randomized dietary study, participations with metabolic syndrome had significant changes in non-HDL-C , LDL-C to HDL-C ratio, and Apo B to Apo A1 ratio, which has been reported adherence to HND improved lipid profile37. The gene discussed is INS; the disease is familial hypercholesterolemia.