It is thus tempting to speculate that basic cellular mechanisms disturbed in mutants of SEC61A1 may play a role in the course of channelopathies which however cause various disease and affect different tissues, e.g. pneumonia, tumor, diabetes, common variable immunodeficiency (CVID), and as suggested here ADPLD6,10. The gene discussed is SEC61A1; the disease is common variable immunodeficiency.