Furthermore, according to the CPTAC dataset, the ACADM protein was downregulated in colon cancer, breast cancer, HNSC, clear cell RCC, pancreatic adenocarcinoma, and hepatocellular carcinoma but upregulated in lung carcinoma and UCEC (Fig. 1B, P < 0.001). The gene discussed is ACADM; the disease is pancreatic adenocarcinoma.