Sampson et al. reported the requisite involvement of gut microbiota to elicit synucleinopathies in a PD model using wild-type and Thy1-α-synuclein genotype mice, in which the germ-free Thy1-α-synuclein genotype demonstrated limited motor and GI dysfunction compared with specific pathogen-free counterparts20. The gene discussed is THY1; the disease is synucleinopathy.