TRIM29 and infection: In line with these findings, infection with the cardiotropic viruses CVB3 and EMCV dramatically reduced the viability of both human (Supplementary Fig. 1j) and mouse (Fig. 1i) cardiomyocytes, whereas TRIM29 knockdown or knockout significantly rescued the viability of cardiomyocytes infected by CVB3 and EMCV (Supplementary Fig. 1j, Fig. 1i).