In this study, we discovered that TRIM29 was an essential regulator of PERK-mediated signaling pathways for causing pathogenesis of viral myocarditis and that the TRIM29-PERK axis could be targeted to reduce viral myocarditis in a mouse model of CVB3-induced myocarditis in vivo (Fig. 8). The gene discussed is EIF2AK3; the disease is viral myocarditis.