To further investigate the role of cardiomyocyte-specific TRIM29 in controlling the pathogenesis of viral myocarditis in vivo, we crossed Trim29-targetd mice with FRT deleter (Rosa26-FLPe) mice to generate Trim29-flox mice (Trim29fl/fl), which were further crossed with αMyHC- Cre (WTMyHC-Cre) transgenic mice to generate cardiomyocyte-specific Trim29 knockout mice, Trim29fl/fl;αMyHC-Cre (Trim29MyHC-KO) (Supplementary Fig. 4a). The gene discussed is FLT1; the disease is viral myocarditis.