Corroboratively, our Trim29 total knockout (Trim29–/–) and cardiomyocyte-specific Trim29 knockout (Trim29MyHC-KO) mouse models displayed resistance to viral myocarditis, which were achieved through improved cardiac function, enhanced cardiac antiviral responses, and curtailed PERK-driven ER stress, apoptosis and immunosuppressive mMDSC. This evidence concerns the gene EIF2AK3 and viral myocarditis.