Next, we intraperitoneally infected Trim29fl/fl, WTMyHC-Cre and Trim29MyHC-KO mice with the cardiotropic virus CVB3 and further evaluated the importance of cardiomyocyte-specific TRIM29 expression in controlling the pathogenesis of viral myocarditis in vivo. The gene discussed is TRIM29; the disease is viral myocarditis.