BAs provide complex physiological modulation by binding to Farnesoid X Receptor (FXR) and Takeda G Protein-Coupled Receptor 5 (TGR5), the canonical BA receptors, while exerting effects at other more recently characterized non-canonical BA receptors.4,5 Alterations in BA physiology are directly correlated to the pathogenesis of cardiometabolic, inflammatory, and neoplastic diseases.6 Hence, the complex role of BAs on physiology provides ample targets for drug discovery. This evidence concerns the gene NR1H4 and neoplasm.