AKT1 and hepatocellular carcinoma: FGF15/19-[FGFR4/βK] axis activity directly activates mitogenic signaling pathways within hepatocytes, such as PI3K-Akt and Ras-Raf-MEK-ERK, being strongly associated with the promotion of human hepatocellular carcinoma.529,530 Alongside the direct promotion of hepatocellular carcinoma, FGFR4/βK prevents ferroptosis within human hepatocytes and breast tissue.