Furthermore, gut FXR agonism in HC diet mice via FGF15 secretion represses hepatic CYP7A1, LDLr, and ABCG8 expression, but paradoxically has no activity on inducing gut ABCG5/ABCG8 expression, further driving hypercholesterolemia. Here, ABCG8 is linked to familial hypercholesterolemia.