CHRM3 and cholangiocarcinoma: Muscarinic receptors 2 (CHRM2) and 3 (CHRM3) are Gi and Gq coupled G-protein coupled receptors, respectively, and both may be agonized by taurine conjugated BAs.302 CHRM2 and CHRM3 overexpression is associated with the initiation and progression of colon, gastric, and pancreatic cancers.303–306 In addition, taurine conjugated LCA has been found to induce cholangiocarcinoma as a downstream result of muscarinic agonism.307