GPBAR1 and hydrops fetalis: In C57BL/6J mice INT-777 has been found to strongly induce GLP-1 secretion, enhance insulin-induced glucose uptake into skeletal muscle, protect against HF DIO mice via DIO2/UCP1 induction, protect against steatosis by repressing hepatic triglyceride synthesis, and inhibit gluconeogenesis by inhibition of FOXO1 and repression of G6Pase/PEPCK.380,649 The positive allosteric modulators B1 and A1 have been found to increase the intrinsic efficacy of CDCA agonism at TGR5, but not increase total maximal cAMP induction.632