Moreover, neither expression of the main mucus protein Muc2 nor the intestinal mucosal host defense proteins regenerating islet-derived protein 3-gamma (Reg3γ), deleted in malignant brain tumors 1 (Dmbt1), mouse beta defensin 3 (mBD3), mouse beta defensin 4 (mBD4) and LY6/PLAUR domain containing 8 (Lypd8), displayed a similar microbiota-diet dependency (Fig. 1G). Here, MBD4 is linked to brain neoplasm.