CircBRD7 plays a pivotal role in the transcriptional activation and expression of its host gene BRD7. This is accomplished through the enhancement of histone 3 lysine 27 acetylation (H3K27ac) enrichment within the promoter region of BRD7. Consequently, a positive feedback loop is established between circBRD7 and BRD7, exerting inhibitory effects on the cell proliferation, migration, invasion, and metastasis of NPC [49]. The gene discussed is BRD7; the disease is nasopharyngeal carcinoma.