In line with the identification of an obesity-related LPHN1 variant, the locus of LPHN1 (19p13.3-p13.11) has already previously been linked to childhood obesity.71 Furthermore, in a study on the effects of LPHN1 on cognitive function that characterized ten human individuals with different LPHN1 mutations causing neurodevelopmental disorders, four out of these patients were reported to be overweight.52 Thus, it seems likely that the mutations in LPHN1 might contribute to the overweight development, although it was not investigated in the respective study. Here, ADGRL1 is linked to obesity disorder.