Consistent with our findings on the role of LPHN1 in the regulation of energy balance and food intake in mice, the analysis of human adipose tissue RNA-seq data from the Leipzig Childhood Adipose Tissue cohort69,70 revealed two novel rare variants of LPHN1 with one of these identified in a child suffering from overweight/obesity (hLPHN1(G1321fs)). The gene discussed is ADGRL1; the disease is obesity due to melanocortin 4 receptor deficiency.