GCG and obesity due to melanocortin 4 receptor deficiency: For example, in obese individuals leptin, insulin, and resistin levels are increased,46,47 while adiponectin, ghrelin, and GLP-1 amounts are usually reduced.48,49 To address the question whether the absence of LPHN1 and the concomitant obesity in mice have a similar effect on these hormones, we measured blood serum levels of different adipokines (Fig. 4a).