In alcoholic liver disease (ALD), EPL have been found to protect against fibrosis in animal models including baboons [15] and mice [16], with a putative mechanism of action involving the downregulation of cytochrome P450 2E1 (CYP2E1) and reduction of CYP2E1-derived oxidative stress, as well as reduction in acetyl-CoA oxidase (ACOX1) expression [16]. The gene discussed is ACOX1; the disease is alcoholic liver diseases.