CD274 and autoimmune disease: The PD-L1-PD-1 pathway's importance has gained recognition in autoimmune diseases (Jin et al. 2010; Pedoeem et al. 2014) with studies showing that the PD-1 pathway can attenuate T cell activation and confer protection against autoimmune pathologies, as observed in GvHD (Cassady et al. 2018), type I diabetes (Falcone and Fousteri 2020) and SLE (Liao et al. 2017).