We know that tumor development is ultimately caused by mutations in genes, and we further analyzed the mutations in PRMT in HNSC and found that overall, the frequency of mutations in PRMT is not high, with only PRMT4 also called CARM1 (1.4%), PRMT 5 (1%) and PRMT 8 (1.7%) having a relative mutation frequency greater than 1% (Figure 1B). This evidence concerns the gene CARM1 and neoplasm.