To investigate the role of PRMT in the development of HNSC, we first analyzed the expression levels of PRMT family members (PRMT1-PRMT9) in tumors using TCGA data, and we found that PRMT6 and PRMT9, the other PRMT family members, had significantly elevated expression in tumor tissues (Figure 1A). The gene discussed is PRMT1; the disease is neoplasm.