The crude rate of major birth defects in the GLP1-RA-exposed women was 2.6%, aligning with the prevalence of major birth defects as reported by EUROCAT which was 2.6% including genetic anomalies for the years 2005–2021.27–29 This rate is also equivalent to that observed in the reference group with diabetes in our study (2.3%). This evidence concerns the gene GCG and diabetes mellitus.