Significant differences in immunophenotypes between risk groups were found by comparing PCa immune subtype proportions in different risk groups, with significantly higher proportions of C1 (Wound Healing) subtype, C2 (IFN-γ Dominant) subtype, and C4 (Lymphocyte Depleted) subtype and significantly lower proportions of C3 (Inflammatory) subtype in the high-risk group (Figure 10A, p=0.001). Here, IFNG is linked to posterior cortical atrophy.